Compile Data Set for Download or QSAR
maximum 50k data
Found 75 of ec50 data for complexid = 50000022
LigandPNGBDBM50126036(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  0.100nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126320(1-{[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-m...)
Affinity DataEC50:  0.5nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50135353(5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataEC50:  0.5nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126322(4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...)
Affinity DataEC50: >1nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153785(4-((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)-2-...)
Affinity DataEC50:  1.20nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153168(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-am...)
Affinity DataEC50:  1.34nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153170(6-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-me...)
Affinity DataEC50:  1.57nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153797(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataEC50:  1.60nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153169(3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-benzyl)-3H-i...)
Affinity DataEC50:  1.65nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126041(6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imi...)
Affinity DataEC50:  2.74nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126317(1-{2-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-acetyl}...)
Affinity DataEC50:  3.90nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
LigandPNGBDBM16181(1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imid...)
Affinity DataEC50:  4nMAssay Description:Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13382(3-(3-chlorophenyl)-4-{[(4-cyanophenyl)(1-methyl-1H...)
Affinity DataEC50:  5.20nMAssay Description:Transcriptional repression in HepG2 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153166(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Affinity DataEC50:  7.70nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153166(3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Affinity DataEC50:  7.70nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151520(3-{4-(3-chlorophenyl)-5-[4-cyanophenyl(1-methyl-1H...)
Affinity DataEC50:  9nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151519(4-[[1-(3-Chloro-benzyl)-4-(3-chloro-phenyl)-6-oxo-...)
Affinity DataEC50:  10nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151521(4-(3-Chloro-phenyl)-5-[(4-cyano-phenyl)-(3-methyl-...)
Affinity DataEC50:  11nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157246(6''-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(...)
Affinity DataEC50:  11nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157270(6''-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(...)
Affinity DataEC50:  13nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151516(5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Affinity DataEC50:  15nMAssay Description:Binding affinity of compound towards Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151515(4-[[4-(3-Chloro-phenyl)-1-(3-fluoro-benzyl)-6-oxo-...)
Affinity DataEC50:  15nMAssay Description:In vitro inhibitory activity against Factor XaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM17325((2S)-2-[(4-{[butyl(2-cyclohexylethyl)amino]methyl}...)
Affinity DataEC50:  16nMAssay Description:Effective concentration against H-ras processing in NIH 3T3 cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50153783(5-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...)
Affinity DataEC50:  16nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153164(CHEMBL435285 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Affinity DataEC50:  16nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153171(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Affinity DataEC50:  16.7nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153776(5-((5-(((5-cyano-3'-ethoxybiphenyl-2-yl)methoxy)me...)
Affinity DataEC50:  17nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153769(5-(3-Chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imi...)
Affinity DataEC50:  21nMAssay Description:Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells at 100 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153173(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataEC50:  21.9nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126323(1-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-propion...)
Affinity DataEC50:  28nMAssay Description:Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153791(6-((5-((2-(benzo[d][1,3]dioxol-5-yl)-4-cyanobenzyl...)
Affinity DataEC50:  29nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157277(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Affinity DataEC50:  30nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126326(1-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)
Affinity DataEC50:  31nMAssay Description:Inhibition of Ras farnesylation in Human Ha-Ras oncogene-transformed BALB/c 3T3 cells (EJ3 cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153175(6-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethoxymethy...)
Affinity DataEC50:  32nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153796(6-(((1-(4-chlorobenzyl)-1H-imidazol-5-yl)methoxy)m...)
Affinity DataEC50:  34nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153174(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataEC50:  52nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153174(6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)me...)
Affinity DataEC50:  52nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157238(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Affinity DataEC50:  53nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153167(6-{3-[3-(4-Cyano-benzyl)-3H-imidazol-4-yl]-3-hydro...)
Affinity DataEC50:  57.5nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153778(6-((1-(4-cyano-3-(naphthalen-1-yl)benzyl)-1H-imida...)
Affinity DataEC50:  60nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153792(4''-Acetyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylm...)
Affinity DataEC50:  77nMAssay Description:Inhibition of H-Ras transformed NIH-3T3-cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157254(5-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)...)
Affinity DataEC50:  85nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157256(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Affinity DataEC50:  89nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50157240(6-[(6-Cyano-2''-trifluoromethyl-biphenyl-3-yl)-(3-...)
Affinity DataEC50:  90nMAssay Description:Effective concentration against H-ras processing in transformed NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50126325(4-Cyano-5-naphthalen-1-yl-3,6-dihydro-2H-pyridine-...)
Affinity DataEC50:  97nMAssay Description:In vitro inhibition of geranylgeranyltransferase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM14459((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...)
Affinity DataEC50:  100nMAssay Description:Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50153177(CHEMBL187809 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Affinity DataEC50:  100nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50153176(4''-tert-Butyl-6-[3-(4-cyano-benzyl)-3H-imidazol-4...)
Affinity DataEC50: >100nMAssay Description:Reduced farnesylation in H-Ras NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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